6bww
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of an acetate and Cymal-5 bound cytochrome P450 2B4 F429H mutant== | |
| - | + | <StructureSection load='6bww' size='340' side='right' caption='[[6bww]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bww]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BWW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bww OCA], [http://pdbe.org/6bww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bww RCSB], [http://www.ebi.ac.uk/pdbsum/6bww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bww ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CP2B4_RABIT CP2B4_RABIT]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Unspecific monooxygenase]] | ||
[[Category: Waskell, L]] | [[Category: Waskell, L]] | ||
| + | [[Category: Yang, Y T]] | ||
| + | [[Category: Acetate cymal-5]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: P450 2b4]] | ||
Revision as of 08:17, 19 December 2018
Crystal structure of an acetate and Cymal-5 bound cytochrome P450 2B4 F429H mutant
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