3bz8

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|PDB= 3bz8 |SIZE=350|CAPTION= <scene name='initialview01'>3bz8</scene>, resolution 2.20&Aring;
|PDB= 3bz8 |SIZE=350|CAPTION= <scene name='initialview01'>3bz8</scene>, resolution 2.20&Aring;
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+997'>AC1</scene>, <scene name='pdbsite=AC2:Vo4+Binding+Site+For+Residue+A+998'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+A+999'>AC3</scene>, <scene name='pdbsite=AC4:Adp+Binding+Site+For+Residue+A+1000'>AC4</scene>, <scene name='pdbsite=AC5:Edo+Binding+Site+For+Residue+A+1001'>AC5</scene> and <scene name='pdbsite=AC6:Bl6+Binding+Site+For+Residue+A+800'>AC6</scene>
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+997'>AC1</scene>, <scene name='pdbsite=AC2:Vo4+Binding+Site+For+Residue+A+998'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+A+999'>AC3</scene>, <scene name='pdbsite=AC4:Adp+Binding+Site+For+Residue+A+1000'>AC4</scene>, <scene name='pdbsite=AC5:Edo+Binding+Site+For+Residue+A+1001'>AC5</scene> and <scene name='pdbsite=AC6:Bl6+Binding+Site+For+Residue+A+800'>AC6</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>, <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=BL6:'>BL6</scene>
+
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BL6:(3AS)-3A-HYDROXY-7-METHYL-1-PHENYL-1,2,3,3A-TETRAHYDRO-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE'>BL6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= mhcA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum])
|GENE= mhcA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum])
 +
|DOMAIN=
 +
|RELATEDENTRY=[[1yv3|1YV3]], [[3bz7|3BZ7]], [[3bz9|3BZ9]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bz8 OCA], [http://www.ebi.ac.uk/pdbsum/3bz8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bz8 RCSB]</span>
}}
}}
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[[Category: Allingham, J S.]]
[[Category: Allingham, J S.]]
[[Category: Rayment, I.]]
[[Category: Rayment, I.]]
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[[Category: ADP]]
 
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[[Category: BL6]]
 
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[[Category: EDO]]
 
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[[Category: MG]]
 
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[[Category: VO4]]
 
[[Category: actin-binding]]
[[Category: actin-binding]]
[[Category: atp-binding]]
[[Category: atp-binding]]
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[[Category: phosphoprotein]]
[[Category: phosphoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 16:01:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:29:48 2008''

Revision as of 02:29, 31 March 2008

Image:3bz8.jpg


PDB ID 3bz8

Drag the structure with the mouse to rotate
, resolution 2.20Å
Sites: , , , , and
Ligands: , , , ,
Gene: mhcA (Dictyostelium discoideum)
Related: 1YV3, 3BZ7, 3BZ9


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II


Overview

Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.

About this Structure

3BZ8 is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:15750603

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