3c0m
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= aerA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 Aeromonas hydrophila]) | |GENE= aerA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 Aeromonas hydrophila]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[3c0n|3C0N]], [[3c0o|3C0O]], [[1pre|1PRE]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c0m OCA], [http://www.ebi.ac.uk/pdbsum/3c0m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3c0m RCSB]</span> | ||
}} | }} | ||
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[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:29:58 2008'' |
Revision as of 02:29, 31 March 2008
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| , resolution 2.88Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | aerA (Aeromonas hydrophila) | ||||||
| Related: | 3C0N, 3C0O, 1PRE
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the proaerolysin mutant Y221G
Overview
Aerolysin is chiefly responsible for the pathogenicity of Aeromonas hydrophila, a bacterium associated with diarrhoeal diseases and deep wound infections. Like many other microbial toxins, the protein changes in a multistep process from a completely water-soluble form to produce a transmembrane channel that destroys sensitive cells by breaking their permeability barriers. Here we describe the structure of proaerolysin determined by X-ray crystallography at 2.8 A resolution. The protoxin (M(r) 52,000) adopts a novel protein fold. Images of an aerolysin oligomer derived from electron microscopy have assisted in constructing a model of the membrane channel and have led to the proposal of a scheme to account for insertion of the protein into lipid bilayers to form ion channels.
About this Structure
3C0M is a Single protein structure of sequence from Aeromonas hydrophila. Full crystallographic information is available from OCA.
Reference
Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states., Parker MW, Buckley JT, Postma JP, Tucker AD, Leonard K, Pattus F, Tsernoglou D, Nature. 1994 Jan 20;367(6460):292-5. PMID:7510043
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