Ras-related protein Rab
From Proteopedia
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| - | <StructureSection load='1oix' size='340' side='right' caption=' | + | <StructureSection load='1oix' size='340' side='right' caption='Human Rab-11A complex with GDP, phosphate and Mg+2 ion (green) (PDB code [[1oix]])' scene=''> |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
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| + | Rab-11A undergoes a conformation change of two switch regions between its inactive GDP-bound structure and its active GTP-bound structure. GDP forms numerous interactions at the active site located at the surface of the protein<ref>PMID:14699104</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:29, 19 December 2018
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3D structures of Ras-related protein Rab
Updated on 19-December-2018
References
- ↑ Bhuin T, Roy JK. Rab11 in disease progression. Int J Mol Cell Med. 2015 Winter;4(1):1-8. PMID:25815277
- ↑ Pasqualato S, Senic-Matuglia F, Renault L, Goud B, Salamero J, Cherfils J. The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes. J Biol Chem. 2004 Mar 19;279(12):11480-8. Epub 2003 Dec 29. PMID:14699104 doi:10.1074/jbc.M310558200
