Base stacking
From Proteopedia
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| - | '''Base stacking''' is a common arrangement of nucleobases found in the three dimensional structure of nucleic acids. Bases (or base pairs) are planar, and these planes stack at contact distance (about 3.4 Angstrom), excluding water and maximizing Van der | + | '''Base stacking''' is a common arrangement of nucleobases found in the three dimensional structure of nucleic acids. Bases (or base pairs) are planar, and these planes stack at contact distance (about 3.4 Angstrom), excluding water and maximizing Van der Waals interactions. In terms of structural stability, the stacking interactions of bases play a larger role than the hydrogen bonds of the bases for nucleic acids in aqueous solution.<ref> PMID:16449200</ref> |
<StructureSection load='' size='340' side='right' caption='' scene='80/804504/Dna/1'> | <StructureSection load='' size='340' side='right' caption='' scene='80/804504/Dna/1'> | ||
Revision as of 18:08, 20 December 2018
Base stacking is a common arrangement of nucleobases found in the three dimensional structure of nucleic acids. Bases (or base pairs) are planar, and these planes stack at contact distance (about 3.4 Angstrom), excluding water and maximizing Van der Waals interactions. In terms of structural stability, the stacking interactions of bases play a larger role than the hydrogen bonds of the bases for nucleic acids in aqueous solution.[1]
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References
- ↑ Yakovchuk P, Protozanova E, Frank-Kamenetskii MD. Base-stacking and base-pairing contributions into thermal stability of the DNA double helix. Nucleic Acids Res. 2006 Jan 31;34(2):564-74. doi: 10.1093/nar/gkj454. Print 2006. PMID:16449200 doi:http://dx.doi.org/10.1093/nar/gkj454
