3jya

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==Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors==
==Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors==
<StructureSection load='3jya' size='340' side='right' caption='[[3jya]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3jya' size='340' side='right' caption='[[3jya]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jya OCA], [http://pdbe.org/3jya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jya RCSB], [http://www.ebi.ac.uk/pdbsum/3jya PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jya OCA], [http://pdbe.org/3jya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jya RCSB], [http://www.ebi.ac.uk/pdbsum/3jya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jya ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/3jya_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/3jya_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
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[[Category: Cytoplasm]]
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Manganese]]
[[Category: Manganese]]
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[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Pim-1]]
[[Category: Pim-1]]
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[[Category: Polymorphism]]
[[Category: Proto-oncogene]]
[[Category: Proto-oncogene]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 08:55, 26 December 2018

Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors

3jya, resolution 2.10Å

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