This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


ADP-ribose pyrophosphatase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 8: Line 8:
ADPRP contains two domains: the <scene name='48/488514/Cv/9'>N-terminal domain responsible for dimer stabilization</scene> and the C-terminal which contains the active site. The C-terminal domain contains the <scene name='48/488514/Cv/10'>Nudix (Nucleoside Diphosphate linked to X) sequence</scene> which is typical to pyrophosphatases and binds the metal ion. <scene name='48/488514/Cv/15'>Residues from both monomers of ADPRP participate in the active site</scene>.<ref>PMID:12135348</ref> Water molecules are shown as red spheres.
ADPRP contains two domains: the <scene name='48/488514/Cv/9'>N-terminal domain responsible for dimer stabilization</scene> and the C-terminal which contains the active site. The C-terminal domain contains the <scene name='48/488514/Cv/10'>Nudix (Nucleoside Diphosphate linked to X) sequence</scene> which is typical to pyrophosphatases and binds the metal ion. <scene name='48/488514/Cv/15'>Residues from both monomers of ADPRP participate in the active site</scene>.<ref>PMID:12135348</ref> Water molecules are shown as red spheres.
 +
*<scene name='48/488514/Cv/16'>Interactions of Mg+2 ion cluster</scene>.
 +
*<scene name='48/488514/Cv/17'>1st Mg+2 ion coordination site</scene>.
 +
*<scene name='48/488514/Cv/18'>2nd Mg+2 ion coordination site</scene>.
 +
*<scene name='48/488514/Cv/19'>3rd Mg+2 ion coordination site</scene>.
</StructureSection>
</StructureSection>
==3D structures of ADP-ribose pyrophosphatase==
==3D structures of ADP-ribose pyrophosphatase==

Revision as of 11:22, 26 December 2018

ADP-ribose pyrophosphatase dimer complex with methylene ADP-ribose, Cl- (large green) and Mg+2 (small green) ions, 1khz

Drag the structure with the mouse to rotate

3D structures of ADP-ribose pyrophosphatase

Updated on 26-December-2018

References

  1. ↑ Gabelli SB, Bianchet MA, Bessman MJ, Amzel LM. The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family. Nat Struct Biol. 2001 May;8(5):467-72. PMID:11323725 doi:10.1038/87647
  2. ↑ Gabelli SB, Bianchet MA, Ohnishi Y, Ichikawa Y, Bessman MJ, Amzel LM. Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase. Biochemistry. 2002 Jul 30;41(30):9279-85. PMID:12135348

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/ADP-ribose_pyrophosphatase"
Personal tools