High affinity nerve growth factor receptor
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''High affinity nerve growth factor receptor''' (TrkA) is a tyrosine kinase receptor. TrkA ligand - nerve growth factor activates the receptor by stabilizing homodimer formation which initiates transautophosphorylation<ref>PMID:9759973</ref>. | + | '''High affinity nerve growth factor receptor''' (TrkA) is a tyrosine kinase receptor. TrkA ligand - nerve growth factor activates the receptor by stabilizing homodimer formation which initiates transautophosphorylation<ref> name="TrkA">PMID:9759973</ref>. |
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
| - | TrkA has a role in the pathogenesis of psoriasis and its inhibitors are studied in the development of novel therapeutics for the disease<ref | + | TrkA has a role in the pathogenesis of psoriasis and its inhibitors are studied in the development of novel therapeutics for the disease<ref name="TrkA"/>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 07:27, 27 December 2018
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3D structures of high affinity nerve growth factor receptor
Updated on 27-December-2018
References
- ↑ name="TrkA">PMID:9759973
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedTrkA - ↑ Wehrman T, He X, Raab B, Dukipatti A, Blau H, Garcia KC. Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron. 2007 Jan 4;53(1):25-38. PMID:17196528 doi:10.1016/j.neuron.2006.09.034
- ↑ Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. PMID:10490030 doi:10.1038/43705
