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This enzyme is involved in step 1 of the subpathway that synthesizes staphyloxanthin from farnesyl diphosphate.

This subpathway is part of the pathway staphyloxanthin biosynthesis, which is itself part of Carotenoid biosynthesis. Staphyloxanthin is a carotenoid, which is responsible for the golden color of S. aureus, and also play the role of virulence factor : it has an antioxidant action that helps the microbe evade death by reactive oxygen species produced by the host immune system. CrtM catalyses the first step of the synthesis of staphyloxanthin with a 2-step mechanism.

Function

Transferase Activity

Metal Ion Binding

Structure

This protein consists of 2 sequence-identical polypeptide chains of 287 amino acids. It has 6 Magnesium ions, 2 Pyrophosphate 2-, 1 L(+)-tartaric acid and 2 (3r)-3-biphenyl-4-yl-1-azabicyclo[2.2.2]octan-3-ol as ligands (substrate or inhibitors, prosthetic groups, cofactors, carbohydrate, metal ions, regardless of whether these are covalently or non-covalently bound to the protein or nucleic acid chains).

Biological process

Pathogenesis

Carotenoid Biosynthetic Process

Disease

Relevance

Structural highlights

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