Sandbox 1498
From Proteopedia
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| - | == 3BPU == | + | ==3BPU== |
| - | 3BPU is a transferase found in Homo sapiens. It is the 3rd PDZ domain of human membrane associated guanylate kinase Q96QZ7, C677S and C709S double mutant. It is encoded by the MAGI1 gene. [https://www.rcsb.org/structure/3bpu | + | <StructureSection load='3BPU' size='350' side='right' caption='' scene=''> |
| - | + | 3BPU is a transferase found in Homo sapiens. It is the 3rd PDZ domain of human membrane associated guanylate kinase Q96QZ7, C677S and C709S double mutant. It is encoded by the MAGI1 gene. [https://www.rcsb.org/structure/3bpu | |
== Function == | == Function == | ||
3BPU is involved in the cell signalisation. It may play a role as a scaffolding protein at cell-cell junctions. It may regulate acid-induced ASIC3<ref >http://www.rcsb.org/pdb/protein/Q9UHC3</ref> currents by modulating its expression at the cell surface through interacting with its PDZ domain. | 3BPU is involved in the cell signalisation. It may play a role as a scaffolding protein at cell-cell junctions. It may regulate acid-induced ASIC3<ref >http://www.rcsb.org/pdb/protein/Q9UHC3</ref> currents by modulating its expression at the cell surface through interacting with its PDZ domain. | ||
It may also allow the interaction of Q96QZ7 with JAM4, providing an adhesion machinery at tight junctions. This may regulate the permeability of kidney glomerulus and small intestinal epithelial cells.<ref>https://www.uniprot.org/citations/12773569</ref> | It may also allow the interaction of Q96QZ7 with JAM4, providing an adhesion machinery at tight junctions. This may regulate the permeability of kidney glomerulus and small intestinal epithelial cells.<ref>https://www.uniprot.org/citations/12773569</ref> | ||
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== Structure == | == Structure == | ||
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This quaternary structure which leads to the function could be influenced by cristal contacts because these one make bonds with the asymmetric unit. [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bpu] | This quaternary structure which leads to the function could be influenced by cristal contacts because these one make bonds with the asymmetric unit. [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bpu] | ||
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| + | == Interactions with ligands == | ||
Parler des interactions avec les ions Zn | Parler des interactions avec les ions Zn | ||
https://www.rcsb.org/3d-view/3BPU?preset=ligandInteraction&sele=ZN | https://www.rcsb.org/3d-view/3BPU?preset=ligandInteraction&sele=ZN | ||
3BPU is mainly made of components which lead to hydrophobic and polar (charged or uncharged) interactions [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bpu] | 3BPU is mainly made of components which lead to hydrophobic and polar (charged or uncharged) interactions [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bpu] | ||
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== References == | == References == | ||
<references/> | <references/> | ||
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| + | </StructureSection> | ||
Revision as of 14:02, 30 December 2018
3BPU
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