Epithelial discoidin domain-containing receptor
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Epithelial discoidin domain-containing receptor 1''' (DDR1) is an extracellular matrix-sensing receptor [[Tyrosine kinase]] which is activated by collagen and is expressed in bronchial epithelium. It is responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. | + | '''Epithelial discoidin domain-containing receptor 1''' (DDR1) is an extracellular matrix-sensing receptor [[Tyrosine kinase]] which is activated by collagen and is expressed in bronchial epithelium. It is responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>. |
== Disease == | == Disease == | ||
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| + | DDR1 promotes inflammation in atherosclerosis, lung fibrosis and kidney injury<ref name="DDR1"/> | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
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| + | DDR1 contains a discoidin domain. This domain is about 150 amino acid long and is found in many blood coagulation factors. | ||
Revision as of 07:24, 31 December 2018
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3D structures of epithelial discoidin domain-containing receptor 1
Updated on 31-December-2018
5bvk – hDDR1 kinase domain 564-913 – human
3zos, 4bkj, 4bkj – hDDR1 kinase domain + cancer drug
6few – hDDR1 kinase domain + alport syndrome drug
6fex, 6fil, 6fim, 6fin, 6fio, 6fiq – hDDR1 kinase domain (mutant) + alport syndrome drug
4ckr, 5bvn, 5bvo, 5bvw, 5fdp, 5fdx, 6brj, 6gwr – hDDR1 kinase domain + inhibitor
4ag4 – hDDR1 29-367 domain + antibody
References
- ↑ Roberts ME, Magowan L, Hall IP, Johnson SR. Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production. Eur Respir J. 2011 Jun;37(6):1482-93. doi: 10.1183/09031936.00039710. Epub 2010, Sep 30. PMID:20884741 doi:http://dx.doi.org/10.1183/09031936.00039710
- ↑ 2.0 2.1 Borza CM, Pozzi A. Discoidin domain receptors in disease. Matrix Biol. 2014 Feb;34:185-92. doi: 10.1016/j.matbio.2013.12.002. Epub 2013 Dec, 19. PMID:24361528 doi:http://dx.doi.org/10.1016/j.matbio.2013.12.002
- ↑ Song J, Chen X, Bai J, Liu Q, Li H, Xie J, Jing H, Zheng J. Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumour Biol. 2016 Aug;37(8):11509-21. doi: 10.1007/s13277-016-5021-2. Epub 2016, Mar 28. PMID:27020590 doi:http://dx.doi.org/10.1007/s13277-016-5021-2
- ↑ Toy KA, Valiathan RR, Nunez F, Kidwell KM, Gonzalez ME, Fridman R, Kleer CG. Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer. Breast Cancer Res Treat. 2015 Feb;150(1):9-18. doi: 10.1007/s10549-015-3285-7., Epub 2015 Feb 10. PMID:25667101 doi:http://dx.doi.org/10.1007/s10549-015-3285-7
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
