Neurotrophin
From Proteopedia
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== Function == | == Function == | ||
| - | '''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA, TrkB, TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily. | + | '''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily. |
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
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| + | Alterations in NTs levels were implicated in neurodegenerative disorders such as Alzheimer disease and Huntington disease as well as psychiatric disorders including depression and substance abuse<ref>PMID:16411893</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 09:17, 1 January 2019
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3D structures of neurotrophin
Updated on 01-January-2019
1b8k, 1nt3 – hNT3 – human
3buk – hNT3 + P75NTR
1bnd – hNT3 139-257 + BDNF
1b98 – hNT4 81-210
1b8m, 1hcf – hNT4 81-210 + BDNF
References
- ↑ Facci L, Skaper SD. Culture of rat cerebellar granule neurons and application to identify neuroprotective agents. Methods Mol Biol. 2012;846:23-37. doi: 10.1007/978-1-61779-536-7_3. PMID:22367798 doi:http://dx.doi.org/10.1007/978-1-61779-536-7_3
- ↑ Chao MV, Rajagopal R, Lee FS. Neurotrophin signalling in health and disease. Clin Sci (Lond). 2006 Feb;110(2):167-73. doi: 10.1042/CS20050163. PMID:16411893 doi:http://dx.doi.org/10.1042/CS20050163
