DNA ligase
From Proteopedia
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== Function == | == Function == | ||
| - | '''DNA ligase''' (LigD) is an enzyme which repairs single-stranded breaks in a double-stranded DNA. LigD is activated, in a species-dependent manner, by hydrolysis of ATP or NAD+.<br /> | + | '''DNA ligase''' (LigD) is an enzyme which repairs single-stranded breaks in a double-stranded DNA. LigD is activated, in a species-dependent manner, by hydrolysis of ATP or NAD+. See also [[ATP-dependent DNA ligase from bacteriophage T7]].<br /> |
* Mammalian '''LigD I''' ligates the nascent DNA of the lagging strand.<br /> | * Mammalian '''LigD I''' ligates the nascent DNA of the lagging strand.<br /> | ||
* '''LigD III''' complexes with XRCC1 in the process of nucleotide excision repair.<br /> | * '''LigD III''' complexes with XRCC1 in the process of nucleotide excision repair.<br /> | ||
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**[[2fao]] - PaLigD polymerase domain – ''Pseudomonas aeruginosa''<br /> | **[[2fao]] - PaLigD polymerase domain – ''Pseudomonas aeruginosa''<br /> | ||
**[[2faq]], [[2far]] - PaLigD polymerase domain + ATP + Mn<br /> | **[[2faq]], [[2far]] - PaLigD polymerase domain + ATP + Mn<br /> | ||
| - | **[[1a0i]] – LigD + ATP – Bacteriophage T7<br /> | + | **[[1a0i]] – LigD (mutant) + ATP – Bacteriophage T7<br /> |
**[[4eq5]] – LigD + AMP – ''Thermococcus sibiricus''<br /> | **[[4eq5]] – LigD + AMP – ''Thermococcus sibiricus''<br /> | ||
**[[4d05]] – LigD + AMP - ''Psychromonas'' <br /> | **[[4d05]] – LigD + AMP - ''Psychromonas'' <br /> | ||
Revision as of 11:32, 1 January 2019
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3D Structures of DNA ligase
Updated on 01-January-2019
References
- ↑ Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T. A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell. 2006 Oct 20;24(2):279-91. PMID:17052461 doi:10.1016/j.molcel.2006.08.015
Elevated expression of DNA ligase I in human cancers., Sun DY, Urrabaz R, Nguyen M, Marty J, Stringer S, Cruz E, Medina-Gundrum L, Weitman S., Clinical Cancer Research. 2001; 7(12):4143-4148.
Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene., Harrison C, Ketchen AM, Redhead NJ, O'Sullivan MJ, Melton DW., Cancer Research. 2002; 62(14):4065-4074.
- Created with the participation of Audrey Kuan.
