6nft
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with (4-oxoquinazolin-3(4H)-yl)acetic acid== | |
| - | + | <StructureSection load='6nft' size='340' side='right' caption='[[6nft]], [[Resolution|resolution]] 1.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6nft]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KKG:(4-oxoquinazolin-3(4H)-yl)acetic+acid'>KKG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6dxt|6dxt]], [[6dxh|6dxh]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nft OCA], [http://pdbe.org/6nft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nft RCSB], [http://www.ebi.ac.uk/pdbsum/6nft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nft ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UBP5_HUMAN UBP5_HUMAN]] Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.<ref>PMID:19098288</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ubiquitinyl hydrolase 1]] | ||
| + | [[Category: Arrowmsmith, C M]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Harding, R J]] | ||
| + | [[Category: Mann, M K]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Schapira, M]] | [[Category: Schapira, M]] | ||
| - | [[Category: Edwards, A.M]] | ||
| - | [[Category: Mann, M.K]] | ||
| - | [[Category: Harding, R.J]] | ||
| - | [[Category: Arrowmsmith, C.M]] | ||
| - | [[Category: Bountra, C]] | ||
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Usp5]] | ||
Revision as of 06:13, 2 January 2019
Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with (4-oxoquinazolin-3(4H)-yl)acetic acid
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