Sandbox Reserved 1490

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 26: Line 26:
'''''Diagram : Comparison of the Kinase Activities of Normal and Mutant TIE2 Receptors'''''
'''''Diagram : Comparison of the Kinase Activities of Normal and Mutant TIE2 Receptors'''''
-
(B) Cells infected with wild-type baculovirus (wt) or virus expressing normal TIE2 (R2) or mutant TIE2 (W2). Cells expressing the mutation at position 849 (Arginine à Tryptophan) have an autophosphorylation activity 6 to 10 times higher than wild cells.
+
(B) Cells infected with wild-type baculovirus (wt) or virus expressing normal TIE2 (R2) or mutant TIE2 (W2). Cells expressing the mutation at position 849 (Arginine Tryptophan) have an autophosphorylation activity 6 to 10 times higher than wild cells.
[[Image:Venous Malformations Diagram.jpg]]
[[Image:Venous Malformations Diagram.jpg]]
 +
With this mutation, Venous Malformations (VMs) contain a Disproportionately high ratio of Endothelial Cells (ECs) to Smooth Muscle Cells (SMCs)
With this mutation, Venous Malformations (VMs) contain a Disproportionately high ratio of Endothelial Cells (ECs) to Smooth Muscle Cells (SMCs)
-
Pictures of immunohistochemistry of VMs with Antibodies against Smooth Muscle Cells 𝛂-Actin.
+
'''''Pictures of immunohistochemistry of VMs with Antibodies against Smooth Muscle Cells 𝛂-Actin'''''
B = Abnormal channels
B = Abnormal channels
 +
C = Normal veins (v) and arteries (a)
C = Normal veins (v) and arteries (a)
-
Antibodies directed against SMCs 𝛂-Actin from cells with VMs show that the vessels have a specific and abnormal staining (B) compared to normal vessels (C)
+
 
Scale bars, 200 𝛍m.
Scale bars, 200 𝛍m.
 +
 +
Antibodies directed against SMCs 𝛂-Actin from cells with VMs show that the vessels have a specific and abnormal staining (B) compared to normal vessels (C)
 +
== Relevance ==
== Relevance ==

Revision as of 15:30, 10 January 2019

This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Kinase Domain of Tyrosine-protein kinase receptor TIE-2 (PDB:6MWE)

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Personal tools