Sandbox Reserved 1490
From Proteopedia
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'''''Diagram : Comparison of the Kinase Activities of Normal and Mutant TIE2 Receptors''''' | '''''Diagram : Comparison of the Kinase Activities of Normal and Mutant TIE2 Receptors''''' | ||
- | (B) Cells infected with wild-type baculovirus (wt) or virus expressing normal TIE2 (R2) or mutant TIE2 (W2). Cells expressing the mutation at position 849 (Arginine | + | (B) Cells infected with wild-type baculovirus (wt) or virus expressing normal TIE2 (R2) or mutant TIE2 (W2). Cells expressing the mutation at position 849 (Arginine → Tryptophan) have an autophosphorylation activity 6 to 10 times higher than wild cells. |
[[Image:Venous Malformations Diagram.jpg]] | [[Image:Venous Malformations Diagram.jpg]] | ||
+ | |||
With this mutation, Venous Malformations (VMs) contain a Disproportionately high ratio of Endothelial Cells (ECs) to Smooth Muscle Cells (SMCs) | With this mutation, Venous Malformations (VMs) contain a Disproportionately high ratio of Endothelial Cells (ECs) to Smooth Muscle Cells (SMCs) | ||
- | Pictures of immunohistochemistry of VMs with Antibodies against Smooth Muscle Cells 𝛂-Actin | + | '''''Pictures of immunohistochemistry of VMs with Antibodies against Smooth Muscle Cells 𝛂-Actin''''' |
B = Abnormal channels | B = Abnormal channels | ||
+ | |||
C = Normal veins (v) and arteries (a) | C = Normal veins (v) and arteries (a) | ||
- | + | ||
Scale bars, 200 𝛍m. | Scale bars, 200 𝛍m. | ||
+ | |||
+ | Antibodies directed against SMCs 𝛂-Actin from cells with VMs show that the vessels have a specific and abnormal staining (B) compared to normal vessels (C) | ||
+ | |||
== Relevance == | == Relevance == |
Revision as of 15:30, 10 January 2019
This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543. |
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Kinase Domain of Tyrosine-protein kinase receptor TIE-2 (PDB:6MWE)
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644