Sandbox Reserved 1495
From Proteopedia
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== Generalities == | == Generalities == | ||
| - | Clathrin is a 3 legged protein with 3 heavy chains and 3 light chains. It has a '''triskelion''' shape (A tryskelion consists of three bent limbs radiating from a centre) and can self-assembled into a '''polyhedral''' structure arround vesicles of eukaryotic cells. Triskelia can polymerize into | + | Clathrin is a 3 legged protein with 3 heavy chains and 3 light chains. It has a '''triskelion''' shape (A tryskelion consists of three bent limbs radiating from a centre) and can self-assembled into a '''polyhedral''' structure arround vesicles of eukaryotic cells. Triskelia can polymerize into cage or even flat lattice, depending on the ratio hexagon/pentagon. A tryskelion consists of three bent limbs radiating from a centre. |
<Structure load='3LVG' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='3LVG' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
Revision as of 15:43, 10 January 2019
Contents |
Generalities
Clathrin is a 3 legged protein with 3 heavy chains and 3 light chains. It has a triskelion shape (A tryskelion consists of three bent limbs radiating from a centre) and can self-assembled into a polyhedral structure arround vesicles of eukaryotic cells. Triskelia can polymerize into cage or even flat lattice, depending on the ratio hexagon/pentagon. A tryskelion consists of three bent limbs radiating from a centre.
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Function
Communication beetween the different compartiments of eukaryotic cell and plasma membrane is allowed by vesicles, which convey molecules within the cytoplasm. Clathrin are involved in the formation of those vesicles in a process named clathrin mediated endocytosis. Clathrins form a skeleton around the vesicle once several protein are assembled. The coated vesicles like so formed will then lose their round protein skeleton after their departure from the initial compartment because the clathrin cage is dismantled. This phenomena proceeds through five stages: initiation, cargo selection, coat assembly, scission and uncoating. During the cargo selection and the initiation, clathrins polymerize into hexagons and pentagons. The ratio between these two shapes dependents of the cells' curve.
Relevance
Clathrin mediated endocytosis allows the passage of cargoes at the level of neurotransmitter cells... Moreover, this specificity has a major role in signalling, in the motility of cell, in the communication between two cells and cells fate.
Structural highlights
</StructureSection>
References
Molecular mechanism and physiological functions of clathrin‑mediated endocytosisVOLUME 12 | AUGUST 2011 Harvey T. McMahon and Emmanuel Boucrot VOLUME 12 | AUGUST 2011
