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Introduction

The 1ki4 protein is the thymidine kinase from Herpes simplex virus type I complexed with 5-bromothienyldeoxyuridine. The Herpes simplex virus type I also called HSV1 cause highly contagious infections worldwide. In most cases, it is orofacial herpes but there is also a small proportion of genital infections. The thymidine kinase is located in human cells and virus cells like in Herpes simplex virus. In the human cells, it exists two forms called TK1 and TK2. This protein is a phosphotransferase enzyme that catalyses the reaction: Deoxythymidine + ATP  Deoxythymidine monophosphate + ADP

Function

Disease

Relevance

Structural highlights

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