Sandbox Reserved 1487

From Proteopedia

(Difference between revisions)

Revision as of 17:03, 10 January 2019

This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.

To get started:

Click the edit this page tab at the top. Save the page after each step, then edit it again.
Click the 3D button (when editing, above the wikitext box) to insert Jmol.
show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

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This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

1 Introduction
2 Function
3 Disease
4 Relevance
5 Structural highlights

Introduction

The 1ki4 protein is the thymidine kinase from Herpes simplex virus type I complexed with 5-bromothienyldeoxyuridine. The Herpes simplex virus type I also called HSV1 cause highly contagious infections worldwide. In most cases, it is orofacial herpes but there is also a small proportion of genital infections.

The thymidine kinase is located in human cells and virus cells like in Herpes simplex virus. In the human cells, it exists two forms called TK1 and TK2.

This protein is a phosphotransferase enzyme that catalyses the reaction:

Deoxythymidine + ATP --> Deoxythymidine monophosphate + ADP

Function

Disease

The HSV1-TK is located in Herpes simplex type I virus and causes orofacial infections.

Most of the time the orofacial herpes is asymptomatic and and carriers of the infection are unaware of it. Symptoms are vesicular lesions or painful open wounds (burning, itching…) inside the mouth.

HSV1 is transmitted mainly by contact with mucous membranes because of the presence of viral particles in wounds, saliva… It can also be transmitted to the genital sphere during oral sex, which causes genital herpes. In rare cases, the mother can transmit the virus to the new-born during the childbirth. In immunocompromised people, symptoms may be more severe and more frequent.

After the first infection, wounds can reappear, and the frequency depends on person. Antivirals are used to reduce the viral load of people infected but they do not cure the infection. However, a mutation in the HSV1-TK protein causes the resistance of the virus against antivirals in immunocompromised patients.

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

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Sandbox Reserved 1487

From Proteopedia

Revision as of 17:03, 10 January 2019

Your Heading Here (maybe something like 'Structure')

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Introduction

Function

Disease

Relevance

Structural highlights

References

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@@ Line 9: / Line 9: @@
 The 1ki4 protein is the thymidine kinase from Herpes simplex virus type I complexed with 5-bromothienyldeoxyuridine.
 The Herpes simplex virus type I also called HSV1 cause highly contagious infections worldwide. In most cases, it is orofacial herpes but there is also a small proportion of genital infections.
 The thymidine kinase is located in human cells and virus cells like in Herpes simplex virus. In the human cells, it exists two forms called TK1 and TK2.
 This protein is a phosphotransferase enzyme that catalyses the reaction:
 Deoxythymidine + ATP --> Deoxythymidine monophosphate + ADP
@@ Line 17: / Line 19: @@
 == Disease ==
+The HSV1-TK is located in Herpes simplex type I virus and causes orofacial infections.
+Most of the time the orofacial herpes is asymptomatic and and carriers of the infection are unaware of it. Symptoms are vesicular lesions or painful open wounds (burning, itching…) inside the mouth.
+HSV1 is transmitted mainly by contact with mucous membranes because of the presence of viral particles in wounds, saliva… It can also be transmitted to the genital sphere during oral sex, which causes genital herpes. In rare cases, the mother can transmit the virus to the new-born during the childbirth. In immunocompromised people, symptoms may be more severe and more frequent.
+After the first infection, wounds can reappear, and the frequency depends on person. Antivirals are used to reduce the viral load of people infected but they do not cure the infection. However, a mutation in the HSV1-TK protein causes the resistance of the virus against antivirals in immunocompromised patients.
 == Relevance ==