4tss
From Proteopedia
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|PDB= 4tss |SIZE=350|CAPTION= <scene name='initialview01'>4tss</scene>, resolution 2.75Å | |PDB= 4tss |SIZE=350|CAPTION= <scene name='initialview01'>4tss</scene>, resolution 2.75Å | ||
|SITE= <scene name='pdbsite=ZN:Zn+Binding+Site+Between+Adjacent+Molecules'>ZN</scene> | |SITE= <scene name='pdbsite=ZN:Zn+Binding+Site+Between+Adjacent+Molecules'>ZN</scene> | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tss OCA], [http://www.ebi.ac.uk/pdbsum/4tss PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4tss RCSB]</span> | ||
}} | }} | ||
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[[Category: Radhakrishnan, R.]] | [[Category: Radhakrishnan, R.]] | ||
[[Category: Schlivert, P M.]] | [[Category: Schlivert, P M.]] | ||
| - | [[Category: ZN]] | ||
[[Category: signal]] | [[Category: signal]] | ||
[[Category: superantigen]] | [[Category: superantigen]] | ||
[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:40:27 2008'' |
Revision as of 02:40, 31 March 2008
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| , resolution 2.75Å | |||||||
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| Sites: | |||||||
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TOXIC SHOCK SYNDROME TOXIN-1: TETRAGONAL P4(1)2(1)2 CRYSTAL FORM
Overview
The structure of toxic shock syndrome toxin-1 (TSST-1), the causative agent in toxic shock syndrome, has been determined in three crystal forms. The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between two symmetry-related molecules. Although not required for biological activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very low concentrations. In addition, the structure of the tetramutant TSST-1H [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify endotoxin shock, has been determined and refined in a fourth crystal form (R-factor = 0.173 to 1.9 A resolution).
About this Structure
4TSS is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci. 1997 Jun;6(6):1220-7. PMID:9194182
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