5bna
From Proteopedia
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|PDB= 5bna |SIZE=350|CAPTION= <scene name='initialview01'>5bna</scene>, resolution 2.600Å | |PDB= 5bna |SIZE=350|CAPTION= <scene name='initialview01'>5bna</scene>, resolution 2.600Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=PTN:PLATINUM TRIAMINE ION'>PTN</scene> | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=PTN:PLATINUM+TRIAMINE+ION'>PTN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bna OCA], [http://www.ebi.ac.uk/pdbsum/5bna PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5bna RCSB]</span> | ||
}} | }} | ||
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[[Category: Pjura, P.]] | [[Category: Pjura, P.]] | ||
[[Category: Wing, R M.]] | [[Category: Wing, R M.]] | ||
| - | [[Category: PTN]] | ||
[[Category: b-dna]] | [[Category: b-dna]] | ||
[[Category: complexed with drug]] | [[Category: complexed with drug]] | ||
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[[Category: modified]] | [[Category: modified]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:41:00 2008'' |
Revision as of 02:41, 31 March 2008
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| , resolution 2.600Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G
Overview
When cisplatin [cis- diamminodichloroplatinum (II)] is diffused into pre-grown crystals of the B-DNA double-helical dodecamer C-G-C-G-A-A-T-T-C-G-C-G, it binds preferentially to the N7 positions of guanines, with what probably is an aquo bridge between Pt and the adjacent O6 atom of the same guanine. The entire guanine ring moves slightly toward the platinum site, into the major groove. Only three of the eight potential cisplatin binding sites on guanines actually are occupied, and this differential reactivity can be explained in terms of the relative freedom of motion of guanines toward the major groove. This shift of guanines upon ligation may weaken the glycosyl bond and assist in the depurination that leads to mismatch SOS repair and G.C. to T.A. transversion.
About this Structure
5BNA is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G., Wing RM, Pjura P, Drew HR, Dickerson RE, EMBO J. 1984 May;3(5):1201-6. PMID:6539674
Page seeded by OCA on Mon Mar 31 05:41:00 2008
