5eas
From Proteopedia
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|PDB= 5eas |SIZE=350|CAPTION= <scene name='initialview01'>5eas</scene>, resolution 2.25Å | |PDB= 5eas |SIZE=350|CAPTION= <scene name='initialview01'>5eas</scene>, resolution 2.25Å | ||
|SITE= <scene name='pdbsite=MGA:Mg2++Binding+Site'>MGA</scene> and <scene name='pdbsite=MGB:Mg2++Binding+Site'>MGB</scene> | |SITE= <scene name='pdbsite=MGA:Mg2++Binding+Site'>MGA</scene> and <scene name='pdbsite=MGB:Mg2++Binding+Site'>MGB</scene> | ||
| - | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eas OCA], [http://www.ebi.ac.uk/pdbsum/5eas PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5eas RCSB]</span> | ||
}} | }} | ||
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[[Category: Noel, J P.]] | [[Category: Noel, J P.]] | ||
[[Category: Starks, C M.]] | [[Category: Starks, C M.]] | ||
| - | [[Category: MG]] | ||
[[Category: 5-epi-aristolochene synthase]] | [[Category: 5-epi-aristolochene synthase]] | ||
[[Category: isoprenoid biosynthesis]] | [[Category: isoprenoid biosynthesis]] | ||
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[[Category: natural products biosynthesis]] | [[Category: natural products biosynthesis]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:41:17 2008'' |
Revision as of 02:41, 31 March 2008
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| , resolution 2.25Å | |||||||
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| Sites: | and | ||||||
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
5-EPI-ARISTOLOCHENE SYNTHASE FROM NICOTIANA TABACUM
Overview
Terpene cyclases catalyze the synthesis of cyclic terpenes with 10-, 15-, and 20-carbon acyclic isoprenoid diphosphates as substrates. Plants have been a source of these natural products by providing a homologous set of terpene synthases. The crystal structures of 5-epi-aristolochene synthase, a sesquiterpene cyclase from tobacco, alone and complexed separately with two farnesyl diphosphate analogs were analyzed. These structures reveal an unexpected enzymatic mechanism for the synthesis of the bicyclic product, 5-epi-aristolochene, and provide a basis for understanding the stereochemical selectivity displayed by other cyclases in the biosynthesis of pharmacologically important cyclic terpenes. As such, these structures provide templates for the engineering of novel terpene cyclases.
About this Structure
5EAS is a Single protein structure of sequence from Nicotiana tabacum. Full crystallographic information is available from OCA.
Reference
Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase., Starks CM, Back K, Chappell J, Noel JP, Science. 1997 Sep 19;277(5333):1815-20. PMID:9295271
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