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6akl
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Striatin3 in complex with SIKE1 Coiled-coil domain== | |
| - | + | <StructureSection load='6akl' size='340' side='right' caption='[[6akl]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6akl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AKL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6akl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6akl OCA], [http://pdbe.org/6akl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6akl RCSB], [http://www.ebi.ac.uk/pdbsum/6akl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6akl ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIKE1_HUMAN SIKE1_HUMAN]] Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.<ref>PMID:16281057</ref> [[http://www.uniprot.org/uniprot/STRN3_HUMAN STRN3_HUMAN]] Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chen, M]] | ||
| + | [[Category: Zhou, L]] | ||
| + | [[Category: Zhou, Z C]] | ||
| + | [[Category: Coiled-coil domain]] | ||
| + | [[Category: Heterotrimer]] | ||
| + | [[Category: Protein binding]] | ||
Revision as of 12:00, 16 January 2019
Crystal structure of Striatin3 in complex with SIKE1 Coiled-coil domain
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