6c3l
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BCL6 BTB domain with compound 15f== | |
| - | + | <StructureSection load='6c3l' size='340' side='right' caption='[[6c3l]], [[Resolution|resolution]] 1.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6c3l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C3L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EGP:N-[2-(1H-indol-3-yl)ethyl]-N-{3-[(4-methylpiperazin-1-yl)methyl]-1-[2-(morpholin-4-yl)-2-oxoethyl]-1H-indol-6-yl}thiourea'>EGP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c3l OCA], [http://pdbe.org/6c3l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c3l RCSB], [http://www.ebi.ac.uk/pdbsum/6c3l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c3l ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cheng, H]] | ||
| + | [[Category: Cierpicki, T]] | ||
| + | [[Category: Linhares, B]] | ||
| + | [[Category: Xue, F]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Protein binding-inhibitor complex]] | ||
| + | [[Category: Protein-protein interaction]] | ||
Revision as of 12:03, 16 January 2019
Crystal structure of BCL6 BTB domain with compound 15f
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