6d0u
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit== | |
| - | + | <StructureSection load='6d0u' size='340' side='right' caption='[[6d0u]], [[Resolution|resolution]] 3.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6d0u]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D0U FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d0u OCA], [http://pdbe.org/6d0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d0u RCSB], [http://www.ebi.ac.uk/pdbsum/6d0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d0u ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Wilson, I A]] | ||
| + | [[Category: Wu, N C]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: Antiviral protein]] | ||
| + | [[Category: Computational design]] | ||
| + | [[Category: Hemagglutinin]] | ||
| + | [[Category: Influenza]] | ||
Revision as of 12:06, 16 January 2019
Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit
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