6iut

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m (Protected "6iut" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6iut is ON HOLD
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==Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody AVFluIgG01==
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<StructureSection load='6iut' size='340' side='right' caption='[[6iut]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6iut]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IUT FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iut OCA], [http://pdbe.org/6iut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iut RCSB], [http://www.ebi.ac.uk/pdbsum/6iut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iut ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/Q1WDM0_9INFA Q1WDM0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
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__TOC__
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</StructureSection>
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[[Category: Sun, J]]
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[[Category: Wang, P]]
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[[Category: Wang, X]]
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[[Category: Zhang, L]]
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[[Category: Zuo, Y]]
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[[Category: Epitope]]
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[[Category: H5n1]]
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[[Category: Hpai]]
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[[Category: Immune system]]
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[[Category: Influenza virus]]
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[[Category: Major vulnerable site]]
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[[Category: Neutralizing antibody]]
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[[Category: Vaccine development]]

Revision as of 12:13, 16 January 2019

Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody AVFluIgG01

6iut, resolution 2.30Å

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OCA

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