6b6i
From Proteopedia
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<StructureSection load='6b6i' size='340' side='right' caption='[[6b6i]], [[Resolution|resolution]] 2.44Å' scene=''> | <StructureSection load='6b6i' size='340' side='right' caption='[[6b6i]], [[Resolution|resolution]] 2.44Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6b6i]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B6I FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6b6i]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_gii.4 Norovirus gii.4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B6I FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b6i OCA], [http://pdbe.org/6b6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b6i RCSB], [http://www.ebi.ac.uk/pdbsum/6b6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b6i ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b6i OCA], [http://pdbe.org/6b6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b6i RCSB], [http://www.ebi.ac.uk/pdbsum/6b6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b6i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/A0A076EGG6_9CALI A0A076EGG6_9CALI]] 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.[PROSITE-ProRule:PRU00870] | [[http://www.uniprot.org/uniprot/A0A076EGG6_9CALI A0A076EGG6_9CALI]] 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.[PROSITE-ProRule:PRU00870] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Norovirus is the leading cause of acute gastroenteritis worldwide with a yearly reported 700 million cases driving a $60 billion global socioeconomic burden. With no FDA approved therapeutics and the chance for severe chronic infection and life-threatening complications, researchers have identified the protease as a potential target. However, drug development has focused on the norovirus GI.1 strain despite its accounting for less than 5% of all outbreaks. Our lab aims to change focus for norovirus drug design from GI.1 to the highly infective GII.4; responsible for more than 50% of all outbreaks worldwide. With the first published crystal structure of the norovirus GII.4 protease, we have identified several significant differences in the structure and active site that have hindered development of a potent inhibitor targeting the norovirus GII.4 protease. With these new insights, we have begun designing compounds that demonstrate increased inhibition of the clinically most relevant norovirus GII.4 strain. | ||
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| + | Structural and antiviral studies of the human norovirus GII.4 protease.,Muzzarelli KM, Kuiper BD, Spellmon N, Brunzelle JS, Hackett J, Amblard F, Zhou S, Liu P, Kovari IA, Yang Z, Schinazi RF, Kovari LC Biochemistry. 2019 Jan 3. doi: 10.1021/acs.biochem.8b01063. PMID:30605321<ref>PMID:30605321</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6b6i" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Norovirus gii 4]] | ||
[[Category: Amblard, F]] | [[Category: Amblard, F]] | ||
[[Category: Brunzelle, J S]] | [[Category: Brunzelle, J S]] | ||
Revision as of 12:28, 16 January 2019
2.4A resolution structure of human Norovirus GII.4 protease
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