7ins
From Proteopedia
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|PDB= 7ins |SIZE=350|CAPTION= <scene name='initialview01'>7ins</scene>, resolution 2.0Å | |PDB= 7ins |SIZE=350|CAPTION= <scene name='initialview01'>7ins</scene>, resolution 2.0Å | ||
|SITE= <scene name='pdbsite=MCR:M-Cresol+Binding+Site.+Oh+Binds+On+Each+Monomer+To+Oa6+A+...'>MCR</scene> | |SITE= <scene name='pdbsite=MCR:M-Cresol+Binding+Site.+Oh+Binds+On+Each+Monomer+To+Oa6+A+...'>MCR</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CRS:M-CRESOL'>CRS</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=7ins FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ins OCA], [http://www.ebi.ac.uk/pdbsum/7ins PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=7ins RCSB]</span> | ||
}} | }} | ||
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[[Category: Hansen, F B.]] | [[Category: Hansen, F B.]] | ||
[[Category: Korber, F.]] | [[Category: Korber, F.]] | ||
| - | [[Category: CRS]] | ||
| - | [[Category: UNK]] | ||
| - | [[Category: ZN]] | ||
[[Category: hormone]] | [[Category: hormone]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:44:23 2008'' |
Revision as of 02:44, 31 March 2008
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| , resolution 2.0Å | |||||||
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| Sites: | |||||||
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z
Overview
The crystal structure of NPH-insulin, pig insulin cocrystallized with zinc, m-cresol and protamine, has been solved by molecular replacement and refined using restrained least-squares refinement methods. The final crystallographic R factor for all reflections between 2 and 10 A is 19.4%. The insulin molecules are arranged as hexamers with two tetrahedrally coordinated Zn atoms in the central channel and one m-cresol bound to each monomer near His B5. One protamine binding site has been unequivocally identified near a dimer-dimer interface, although most of the polypeptide is crystallographically disordered. The conformation of the insulin moiety and the structural differences between the three unique monomers have been analysed. The zinc and m-cresol environments are described and the nature of the protamine binding site is outlined.
About this Structure
7INS is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.
Reference
Structure of porcine insulin cocrystallized with clupeine Z., Balschmidt P, Hansen FB, Dodson EJ, Dodson GG, Korber F, Acta Crystallogr B. 1991 Dec 1;47 ( Pt 6):975-86. PMID:1772633
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