9hvp
From Proteopedia
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|PDB= 9hvp |SIZE=350|CAPTION= <scene name='initialview01'>9hvp</scene>, resolution 2.8Å | |PDB= 9hvp |SIZE=350|CAPTION= <scene name='initialview01'>9hvp</scene>, resolution 2.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=PHQ:FORMIC ACID BENZYL ESTER'>PHQ</scene> | + | |LIGAND= <scene name='pdbligand=COR:2,4-DIAMINO-1,5-DIPHENYL-3-HYDROXYPENTANE'>COR</scene>, <scene name='pdbligand=PHQ:FORMIC+ACID+BENZYL+ESTER'>PHQ</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=9hvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hvp OCA], [http://www.ebi.ac.uk/pdbsum/9hvp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=9hvp RCSB]</span> | ||
}} | }} | ||
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[[Category: Erickson, J.]] | [[Category: Erickson, J.]] | ||
[[Category: Neidhart, D J.]] | [[Category: Neidhart, D J.]] | ||
| - | [[Category: PHQ]] | ||
[[Category: hydrolase(acid proteinase)]] | [[Category: hydrolase(acid proteinase)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:46:07 2008'' |
Revision as of 02:46, 31 March 2008
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| , resolution 2.8Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE
Overview
A two-fold (C2) symmetric inhibitor of the protease of human immunodeficiency virus type-1 (HIV-1) has been designed on the basis of the three-dimensional symmetry of the enzyme active site. The symmetric molecule inhibited both protease activity and acute HIV-1 infection in vitro, was at least 10,000-fold more potent against HIV-1 protease than against related enzymes, and appeared to be stable to degradative enzymes. The 2.8 angstrom crystal structure of the inhibitor-enzyme complex demonstrated that the inhibitor binds to the enzyme in a highly symmetric fashion.
About this Structure
9HVP is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease., Erickson J, Neidhart DJ, VanDrie J, Kempf DJ, Wang XC, Norbeck DW, Plattner JJ, Rittenhouse JW, Turon M, Wideburg N, et al., Science. 1990 Aug 3;249(4968):527-33. PMID:2200122
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