5y2l
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a group 2 HA binding antibody AF4H1K1 Fab in complex with the 1968 H3N2 pandemic (H3-AC/68) hemagglutinin== | |
| - | + | <StructureSection load='5y2l' size='340' side='right' caption='[[5y2l]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5y2l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y2L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y2l OCA], [http://pdbe.org/5y2l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y2l RCSB], [http://www.ebi.ac.uk/pdbsum/5y2l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y2l ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gao, F G]] | ||
| + | [[Category: Qi, J]] | ||
| + | [[Category: Xiao, H]] | ||
| + | [[Category: Antimicrobial protein]] | ||
| + | [[Category: H3-clade]] | ||
| + | [[Category: Ha]] | ||
| + | [[Category: Influenza virus]] | ||
| + | [[Category: Neutralizing antibody]] | ||
Revision as of 08:09, 30 January 2019
Crystal structure of a group 2 HA binding antibody AF4H1K1 Fab in complex with the 1968 H3N2 pandemic (H3-AC/68) hemagglutinin
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