This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6ekp
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Tryptophan Repressor TrpR from E.coli variant T44L T81M S88Y with Indole-3-acetic acid as ligand== | |
| - | + | <StructureSection load='6ekp' size='340' side='right' caption='[[6ekp]], [[Resolution|resolution]] 1.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ekp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EKP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IAC:1H-INDOL-3-YLACETIC+ACID'>IAC</scene>, <scene name='pdbligand=P3G:3,6,9,12,15-PENTAOXAHEPTADECANE'>P3G</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ejw|6ejw]], [[6ejz|6ejz]], [[6eni|6eni]], [[6enn|6enn]], [[6elb|6elb]], [[6elf|6elf]], [[6elg|6elg]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ekp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ekp OCA], [http://pdbe.org/6ekp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ekp RCSB], [http://www.ebi.ac.uk/pdbsum/6ekp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ekp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI]] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Herud-Sikimic, O]] | ||
[[Category: Hocker, B]] | [[Category: Hocker, B]] | ||
| + | [[Category: Juergens, G]] | ||
[[Category: Shanmugaratnam, S]] | [[Category: Shanmugaratnam, S]] | ||
| - | [[Category: | + | [[Category: Stiel, A C]] |
| - | [[Category: | + | [[Category: Ligand binding]] |
| - | [[Category: | + | [[Category: Transcription]] |
Revision as of 08:17, 30 January 2019
Tryptophan Repressor TrpR from E.coli variant T44L T81M S88Y with Indole-3-acetic acid as ligand
| |||||||||||
