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6f96
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(4-methoxyphenyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide== | |
| - | + | <StructureSection load='6f96' size='340' side='right' caption='[[6f96]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6f96]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F96 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D0K:6-(ethylcarbamoylamino)-4-[(4-methoxyphenyl)amino]-~{N}-pyridin-3-yl-pyridine-3-carboxamide'>D0K</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f96 OCA], [http://pdbe.org/6f96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f96 RCSB], [http://www.ebi.ac.uk/pdbsum/6f96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f96 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GYRB_ECO57 GYRB_ECO57]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fishwick, C W.G]] | ||
| + | [[Category: Lawson, D M]] | ||
[[Category: Maxwell, A]] | [[Category: Maxwell, A]] | ||
| - | [[Category: | + | [[Category: Narramore, S K]] |
| - | [[Category: | + | [[Category: Stevenson, C E.M]] |
| + | [[Category: Binding site]] | ||
| + | [[Category: Dna gyrase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Isomerase]] | ||
| + | [[Category: Pyridine-3-carboxamide]] | ||
| + | [[Category: Topoisomerase iv]] | ||
Revision as of 08:18, 30 January 2019
Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(4-methoxyphenyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide
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