6fcj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Kinetics of Hsp90 inhibitors (title to be refined)== | |
| - | + | <StructureSection load='6fcj' size='340' side='right' caption='[[6fcj]], [[Resolution|resolution]] 2.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6fcj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FCJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D4W:4-[2-(2-chlorophenyl)pyrazol-3-yl]benzene-1,3-diol'>D4W</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fcj OCA], [http://pdbe.org/6fcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fcj RCSB], [http://www.ebi.ac.uk/pdbsum/6fcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fcj ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Eggenweiler, H M]] | ||
| + | [[Category: Lehmann, M]] | ||
[[Category: Musil, D]] | [[Category: Musil, D]] | ||
| - | [[Category: | + | [[Category: Atp binding]] |
| - | [[Category: | + | [[Category: Chaperone]] |
| + | [[Category: Chaperone-chaperone inhibitor complex]] | ||
Revision as of 08:20, 30 January 2019
Kinetics of Hsp90 inhibitors (title to be refined)
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