5xz3
From Proteopedia
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<StructureSection load='5xz3' size='340' side='right' caption='[[5xz3]], [[Resolution|resolution]] 1.86Å' scene=''> | <StructureSection load='5xz3' size='340' side='right' caption='[[5xz3]], [[Resolution|resolution]] 1.86Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5xz3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XZ3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5xz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Apime Apime]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XZ3 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PGRP-S3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7460 APIME])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xz3 OCA], [http://pdbe.org/5xz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xz3 RCSB], [http://www.ebi.ac.uk/pdbsum/5xz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xz3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xz3 OCA], [http://pdbe.org/5xz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xz3 RCSB], [http://www.ebi.ac.uk/pdbsum/5xz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xz3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Peptidoglycan recognition protein SA (PGRP-SA) is a key pattern recognition receptor in the insect innate immune system. PGRP-SA can bind to bacterial PGN and activate the Toll pathway, which triggers the expression and release of antimicrobial peptides to prevent bacterial infection. Here, we report the first structure of Apis mellifera PGRP-SA from Hymenoptera at 1.86 A resolution. The overall architecture of Am-PGRP-SA was similar to the Drosophila PGRP-SA; however, the residues involved in PGN binding groove were not conserved, and the binding pocket was narrower. This structure gives insight into PGN binding characteristics in honeybees. | ||
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| + | Crystal structure of peptidoglycan recognition protein SA in Apis mellifera (Hymenoptera: Apidae).,Liu Y, Zhao X, Naeem M, An J Protein Sci. 2018 Apr;27(4):893-897. doi: 10.1002/pro.3383. Epub 2018 Mar 14. PMID:29396863<ref>PMID:29396863</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5xz3" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Apime]] | ||
[[Category: An, J D]] | [[Category: An, J D]] | ||
[[Category: Huang, J X]] | [[Category: Huang, J X]] | ||
Revision as of 09:22, 30 January 2019
The X-ray structure of Apis mellifera PGRP-SA
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Categories: Apime | An, J D | Huang, J X | Liu, Y J | Zhao, X M | Apis mellifera | Immune system | Pgrp-sa
