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2cag

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Revision as of 15:58, 5 November 2007

Image:2cag.gif

2cag, resolution 2.7Å

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CATALASE COMPOUND II

Overview

Various enzymes use semi-stable ferryl intermediates and free radicals, during their catalytic cycle, amongst them haem catalases. Structures for, two transient intermediates (compounds I and II) of the NADPH-dependent, catalase from Proteus mirabilis (PMC) have been determined by, time-resolved X-ray crystallography and single crystal, microspectrophotometry. The results show the formation and transformation, of the ferryl group in the haem, and the unexpected binding of an anion, during this reaction at a site distant from the haem.

About this Structure

2CAG is a Single protein structure of sequence from Proteus mirabilis with HEM as ligand. The following page contains interesting information on the relation of 2CAG with [Catalase]. Active as Catalase, with EC number 1.11.1.6 Structure known Active Sites: DH and PT. Full crystallographic information is available from OCA.

Reference

Ferryl intermediates of catalase captured by time-resolved Weissenberg crystallography and UV-VIS spectroscopy., Gouet P, Jouve HM, Williams PA, Andersson I, Andreoletti P, Nussaume L, Hajdu J, Nat Struct Biol. 1996 Nov;3(11):951-6. PMID:8901874

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