Major histocompatibility complex

From Proteopedia

Revision as of 11:27, 5 February 2019

spinqualitylabelsall models Human MHC class I antigen (cyan) with β 2-microglobulin (green) and peptide from Hepatitis virus (deeppink) 3ox8 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Major Histocompatibility Complex (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response. MHC class I (Major Histocompatibility Complex Class I) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins[1]. For more details see Effect of HCMV on Major Histocompatibility Complex Class I MR1 Binds Vitamin Metabolites. MHC class II are found in professional antigen-presenting cells like macrophages. These cell surface proteins display peptides from cellular extrinsic proteins[2]. Structural highlights . The [3]. Water molecules shown as red spheres.

3D structures of MHC

Updated on 05-February-2019

References

1. ↑ Raghavan M, Del Cid N, Rizvi SM, Peters LR. MHC class I assembly: out and about. Trends Immunol. 2008 Sep;29(9):436-43. doi: 10.1016/j.it.2008.06.004. PMID:18675588 doi:http://dx.doi.org/10.1016/j.it.2008.06.004
2. ↑ Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol. 2004 Apr;65(4):282-90. PMID:15120183 doi:http://dx.doi.org/10.1016/j.humimm.2004.01.005
3. ↑ Liu J, Chen KY, Ren EC. Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: Towards designing better vaccines. Eur J Immunol. 2011 Jul;41(7):2097-106. doi: 10.1002/eji.201041370. PMID:21538979 doi:10.1002/eji.201041370