CD47

From Proteopedia

Revision as of 13:53, 10 February 2019

spinqualitylabelsall models Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRP α (cyan) and I- ions 2jjs Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Relevance 3 Structural insights Function CD47 (Cluster of Differentiation 47) is a protein which is expressed by cancer cells to avoid detection by the immune system. CD47 is a receptor for thrombospondin-1 and their association influences cell migration and adhesion. CD47 is a receptor for SIRP1 and their association influences inhibition of phagocytosis. CD47 is a receptor for several integrins and their association influences cell migration and adhesion. CD47 leads to cell death via apoptosis. [1] Relevance Antibodies against CD47 were found to bring effective cure against cancer in mice in a variety of cancers tested. CD47 is an antigen on a variety of human cancer cells. Structural insights CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain. (2jjs).[2]

3D Structures of CD47

Updated on 10-February-2019

2jjs, 2jjt, 4kjy – hCD47 extracellular domain (mutant) + SIRP α
2vsc – hCD47 extracellular domain (mutant)
4cmm - hCD47 extracellular domain (mutant) + tyrosine-protein phosphatase non-receptor type substrate
5iwl – hCD47 extracellular domain (mutant) + 5F9 diabody
5tz2, 5tzt, 5tz2 – hCD47 extracellular domain (mutant) + antibody

References

1. ↑ Chao MP, Weissman IL, Majeti R. The CD47-SIRPalpha pathway in cancer immune evasion and potential therapeutic implications. Curr Opin Immunol. 2012 Apr;24(2):225-32. doi: 10.1016/j.coi.2012.01.010. Epub, 2012 Feb 4. PMID:22310103 doi:http://dx.doi.org/10.1016/j.coi.2012.01.010
2. ↑ Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Mol Cell. 2008 Jul 25;31(2):266-77. PMID:18657508 doi:10.1016/j.molcel.2008.05.026