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Each subunit of a medium-chain acyl-CoA dehydrogenase enzyme is composed of three structural domains. The N-terminal 𝛼-helix domain, the 𝛽-sheet domain, and the C-terminal 𝛼-helix domain.

Function

Disease

Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a disorder dealing with fatty acid oxidation and can be characterized by hypoglycemic crisis during stressful conditions. MCADD is the most common metabolic defect of fatty acid oxidation. Medium-chain acyl-CoA dehydrogenase is a flavoprotein that catalyzes the first reaction in 𝛽-oxidation of fatty acids. The resulting effects include a decrease of ketone production and an increase in medium-chain fatty acid concentration. MCADD is passed genetically through an autosomal recessive trait and it is caused by mutations in the medium-chain acyl- CoA dehydrogenase (ACADM) gene. The ACADM gene is located on chromosome 1p31.

Relevance

Structural highlights

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