6i8s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1== | |
| - | + | <StructureSection load='6i8s' size='340' side='right' caption='[[6i8s]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6i8s]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I8S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i8s OCA], [http://pdbe.org/6i8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i8s RCSB], [http://www.ebi.ac.uk/pdbsum/6i8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i8s ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[http://omim.org/entry/613329 613329]]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref> Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lundqvist, T]] | ||
| + | [[Category: Popovic, B]] | ||
| + | [[Category: Vousden, K A]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: Blood clotting]] | ||
| + | [[Category: Fab]] | ||
| + | [[Category: Pai-1]] | ||
| + | [[Category: Plasminogen activator inhibitor-1]] | ||
| + | [[Category: Serpin]] | ||
Revision as of 09:31, 13 February 2019
Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
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