CXC chemokine receptor
From Proteopedia
(Difference between revisions)
| Line 9: | Line 9: | ||
'''CXC chemokine receptors''' bind to cytokines of the CXC chemokine family. '''CXCR4''' is specific for [[Stromal Derived Factor 1]] (SDF-1α, known also as CXCL12). The CXCR4 is used by HIV to infect CD4+ T cells. The biological unit probably is a <scene name='56/566486/Cv/1'>dimer</scene> <ref>PMID:20929726</ref>. '''CXCR1''' recognizes CXC chemokines with ELR amino acids adjacent to the C-terminal CXC motif.<ref>PMID:23086146</ref> | '''CXC chemokine receptors''' bind to cytokines of the CXC chemokine family. '''CXCR4''' is specific for [[Stromal Derived Factor 1]] (SDF-1α, known also as CXCL12). The CXCR4 is used by HIV to infect CD4+ T cells. The biological unit probably is a <scene name='56/566486/Cv/1'>dimer</scene> <ref>PMID:20929726</ref>. '''CXCR1''' recognizes CXC chemokines with ELR amino acids adjacent to the C-terminal CXC motif.<ref>PMID:23086146</ref> | ||
| - | <scene name='43/438522/Cv/ | + | <scene name='43/438522/Cv/10'>Ligand binding cavity with antagonist citrulline</scene> (PDB code [[3oe0]]). |
| - | <scene name='43/438522/Cv/ | + | <scene name='43/438522/Cv/11'>Ligand binding cavity with antagonist citrulline, receptor is in spacefill representation</scene>. |
| - | <scene name='43/438522/Cv/ | + | <scene name='43/438522/Cv/12'>Ligand binding cavity with antagonist citrulline, receptor surface is shown</scene>. |
</StructureSection> | </StructureSection> | ||
Revision as of 07:09, 18 February 2019
| |||||||||||
3D Structures of CXC chemokine receptor
Updated on 18-February-2019
References
- ↑ Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 2010 Oct 7. PMID:20929726 doi:10.1126/science.1194396
- ↑ Park SH, Das BB, Casagrande F, Tian Y, Nothnagel HJ, Chu M, Kiefer H, Maier K, De Angelis AA, Marassi FM, Opella SJ. Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature. 2012 Nov 29;491(7426):779-83. doi: 10.1038/nature11580. Epub 2012 Oct 21. PMID:23086146 doi:http://dx.doi.org/10.1038/nature11580
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
