Cyclic GMP-AMP synthase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The <scene name='59/591942/Cv/ | + | The <scene name='59/591942/Cv/4'>2'3'-cGAMP binds at the lower part of the cleft between the N-lobe and C-lobe of CGAS</scene>.<ref>PMID:24462292</ref> |
</StructureSection> | </StructureSection> | ||
Revision as of 07:10, 18 February 2019
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3D structures of cyclic GMP-AMP synthase
Updated on 18-February-2019
References
- ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458
- ↑ Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep. 2014 Feb 13;6(3):421-30. doi: 10.1016/j.celrep.2014.01.003. Epub 2014, Jan 23. PMID:24462292 doi:http://dx.doi.org/10.1016/j.celrep.2014.01.003
