Cytidine monophosphate kinase

From Proteopedia

Revision as of 07:41, 18 February 2019

spinqualitylabelsall models Structure of E. coli cytidine monophosphate kinase complex with CMP (PDB entry 1kdo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Cytidine monophosphate kinase (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP. [1] Relevance CMK from bacterial pathogens is a target for new antibiotics development. Structural highlights is highly sugar-specific.[2] Water molecules are shown as red spheres.

3D structures of cytidine monophosphate kinase

(Updated on 18-February-2019)

References

1. ↑ Briozzo P, Golinelli-Pimpaneau B, Gilles AM, Gaucher JF, Burlacu-Miron S, Sakamoto H, Janin J, Barzu O. Structures of escherichia coli CMP kinase alone and in complex with CDP: a new fold of the nucleoside monophosphate binding domain and insights into cytosine nucleotide specificity. Structure. 1998 Dec 15;6(12):1517-27. PMID:9862805
2. ↑ Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Barzu O, Gilles AM. Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme. J Mol Biol. 2002 Feb 1;315(5):1099-110. PMID:11827479 doi:10.1006/jmbi.2001.5286