Cytochrome P450 hydroxylase
From Proteopedia
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'''Cytochrome P450 hydroxylase''' (CPH) acts in the in-chain hydroxylation of lauric acid which is required for the development of the male organ in higher plants<ref>PMID:24798002</ref>. CPH hydroxylyzes the anti-cholesterol natural product herbosidiene<ref>PMID:25139567</ref>. | '''Cytochrome P450 hydroxylase''' (CPH) acts in the in-chain hydroxylation of lauric acid which is required for the development of the male organ in higher plants<ref>PMID:24798002</ref>. CPH hydroxylyzes the anti-cholesterol natural product herbosidiene<ref>PMID:25139567</ref>. | ||
| - | *<scene name='77/774654/Cv/ | + | *<scene name='77/774654/Cv/6'>Lauric acid binding site</scene>. |
| - | *<scene name='77/774654/Cv/ | + | *<scene name='77/774654/Cv/7'>Heme group binding site</scene>. |
| - | *<scene name='77/774654/Cv/ | + | *<scene name='77/774654/Cv/8'>Fe coordination site</scene>. |
| - | *<scene name='77/774654/Cv/ | + | *<scene name='77/774654/Cv/9'>Distances between Lauric acid oxygens and heme group Fe</scene> in Cytochrome P450 hydroxylase from ''Steptomyces avermitilis'' (PDB code [[5cwe]]). |
Revision as of 08:06, 18 February 2019
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3D Structures of cytochrome P450 hydroxylase
Updated on 18-February-2019
References
- ↑ Yang X, Wu D, Shi J, He Y, Pinot F, Grausem B, Yin C, Zhu L, Chen M, Luo Z, Liang W, Zhang D. Rice CYP703A3, a cytochrome P450 hydroxylase, is essential for development of anther cuticle and pollen exine. J Integr Plant Biol. 2014 Oct;56(10):979-94. doi: 10.1111/jipb.12212. Epub 2014, Jul 15. PMID:24798002 doi:http://dx.doi.org/10.1111/jipb.12212
- ↑ Yu D, Xu F, Shao L, Zhan J. A specific cytochrome P450 hydroxylase in herboxidiene biosynthesis. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4511-4514. doi:, 10.1016/j.bmcl.2014.07.078. Epub 2014 Aug 6. PMID:25139567 doi:http://dx.doi.org/10.1016/j.bmcl.2014.07.078
