Dynamin

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membran...)
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<StructureSection load='5d3q' size='340' side='right' caption='Human dynamin 1 GTPase+GTPase effector domains complex with GDP and ethylene glycol (PDB code [[5d3q]])' scene=''>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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== Function ==
== Function ==
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'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division. '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>. DNM is a multidomain GTPase. Mammalian genomes contain 3 DNM genes which show ca. 80% homology. '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>. The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and phophotransferase regulation domains.
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'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division. '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>. DNM is a multidomain GTPase. Mammalian genomes contain 3 DNM genes which show ca. 80% homology. '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>. The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and proline- and arginine-rich (PRD) domains.
== Disease ==
== Disease ==

Revision as of 09:20, 19 February 2019

Human dynamin 1 GTPase+GTPase effector domains complex with GDP and ethylene glycol (PDB code 5d3q)

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References

  1. ↑ Taylor MJ, Lampe M, Merrifield CJ. A feedback loop between dynamin and actin recruitment during clathrin-mediated endocytosis. PLoS Biol. 2012;10(4):e1001302. doi: 10.1371/journal.pbio.1001302. Epub 2012 Apr , 10. PMID:22505844 doi:http://dx.doi.org/10.1371/journal.pbio.1001302
  2. ↑ Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F, Smith CL, Youle RJ. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell. 2001 Oct;1(4):515-25. PMID:11703942
  3. ↑ Ferguson SM, De Camilli P. Dynamin, a membrane-remodelling GTPase. Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88. doi: 10.1038/nrm3266. PMID:22233676 doi:http://dx.doi.org/10.1038/nrm3266
  4. ↑ Bitoun M, Maugenre S, Jeannet PY, Lacene E, Ferrer X, Laforet P, Martin JJ, Laporte J, Lochmuller H, Beggs AH, Fardeau M, Eymard B, Romero NB, Guicheney P. Mutations in dynamin 2 cause dominant centronuclear myopathy. Nat Genet. 2005 Nov;37(11):1207-9. Epub 2005 Oct 16. PMID:16227997 doi:ng1657

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Alexander Berchansky, Michal Harel

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