14-3-3 protein

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==3D structures of 14-3-3 proteins (Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}) ==
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*14-3-3 protein σ
 
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** [[1yz5]] – hPRS – human<br />
 
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*14-3-3 protein σ binary complex with peptide
 
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**[[1ywt]], [[5mhc]] – hPRS + phosphopeptide <br />
 
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**[[3lw1]], [[5moc]], [[5mxo]] – hPRS + p53 peptide <br />
 
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**[[3iqj]], [[3iqu]], [[4iea]] – hPRS + Raf-1 peptide <br />
 
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**[[3mhr]] – hPRS + YAP peptide <br />
 
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**[[3p1n]] – hPRS + TASK-3 peptide <br />
 
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**[[3p1p]], [[3p1r]] – hPRS (mutant) + TASK-3 peptide <br />
 
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**[[4dat]], [[4dau]] – hPRS + PADI6 peptide <br />
 
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**[[4jc3]], [[4jdd]] – hPRS + estrogen receptor peptide <br />
 
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**[[4fl5]], [[5btv]], [[5hf3]], [[4y5i]], [[4y32]], [[4y3b]] – hPRS + τ protein peptide <br />
 
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**[[5ltw]] – hPRS (mutant) + HSPB6 <br />
 
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**[[5lu1]], [[5lu2]] – hPRS (mutant) + HSPB6 peptide<br />
 
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**[[4qli]] – hPRS + SNAI1 peptide <br />
 
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**[[5my9]], [[5myc]] – hPRS + LRRK2 peptide <br />
 
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**[[5n5r]], [[5n5t]], [[5n5w]], [[5n75]] – hPRS + taz ps89 peptide <br />
 
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**[[5ok9]], [[5okf]] – hPRS/HSPB6 <br />
 
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**[[5om0]] – hPRS/GLI1 <br />
 
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**[[5oma]] – hPRS/STRAD1 + peptide <br />
 
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*14-3-3 protein σ binary complex with small molecule
 
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**[[3u9x]] – hPRS + pyridoxal phosphate<br />
 
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**[[3t0l]], [[3t0m]], [[4dhm]], [[4dhn]], [[4dho]], [[4dhp]], [[4dhq]], [[4dhr]], [[4dhs]], [[4dht]], [[4dhu]] – hPRS + inhibitor<br />
 
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**[[5oeh]], [[5oeg]] – hPRS + molecular tweezers<br />
 
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*14-3-3 protein σ ternary complex with stabilizer
 
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**[[3p1o]], [[3ux0]], [[4fr3]] – hPRS + TASK-3 peptide + stabilizer<br />
 
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**[[3p1q]], [[3p1s]], [[3spr]], [[3smk]], [[3sml]], [[3smm]], [[3smn]], [[3smo]], [[3sp5]] – hPRS (mutant) + TASK-3 peptide + stabilizer<br />
 
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**[[3iqv]], [[3o8i]] – hPRS + Raf-1 peptide + stabilizer<br />
 
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*14-3-3 protein ζ
 
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**[[1a4o]] – bPRS - bovine<br />
 
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**[[1a37]] – bPRS + Raf peptide <br />
 
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**[[1a38]] – bPRS + R18 peptide <br />
 
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**[[1qja]] – hPRS + phosphopeptide <br />
 
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**[[4wrq]] – hPRS + Chibby peptide <br />
 
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*14-3-3 protein ζ/δ
 
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**[[3rdh]] – hPRS <br />
 
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**[[3rdh]] – hPRS/LKB1 <br />
 
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**[[1qjb]], [[1qja]], [[6eww]] – hPRS + phosphopeptide <br />
 
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**[[2c1j]], [[2c1n]] – hPRS + histone H3 peptide <br />
 
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**[[2o02]], [[4n7g]], [[4n7y]], [[4n84]], [[5j31]] – hPRS + exoenzyme S peptide <br />
 
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**[[2v7d]], [[4hkc]] – hPRS + integrin peptide <br />
 
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**[[5jm4]] – hPRS + peptide <br />
 
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**[[5nas]] – hPRS + PI4KIIIB peptide <br />
 
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**[[5m35]], [[5m36]], [[5m37]] – hPRS + M-phase phosphatase peptide <br />
 
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**[[5ulo]] – hPRS + TBC1D7 peptide <br />
 
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**[[6ejl]] – hPRS + MAP3K 5 peptide <br />
 
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**[[6f08]] – hPRS + SOS-1 peptide <br />
 
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**[[3cu8]], [[3nkx]], [[4fj3]], [[4ihl]] – hPRS + Raf-1 peptide <br />
 
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**[[2wh0]] – hPRS + protein kinase C ε peptide <br />
 
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**[[4bg6]] – hPRS + RND3 peptide <br />
 
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**[[5ewz]], [[5exa]] – hPRS + GRB2-associated protein peptide <br />
 
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**[[5d2d]] – hPRS + CFTR peptide <br />
 
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**[[5d3f]] – hPRS + CFTR peptide + stabilizer<br />
 
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**[[1ib1]] – hPRS + serotonin N-acetyltransferase <br />
 
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*14-3-3 protein γ
 
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**[[4e2e]] – hPRS <br />
 
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**[[2b05]] – hPRS + phosphopeptide <br />
 
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**[[3uzd]] – hPRS + histone deacylase peptide <br />
 
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**[[4j6s]] – hPRS + tyrosine hydroxylase peptide <br />
 
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**[[4o46]] – hPRS + influenza C-terminal peptide <br />
 
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**[[5d3e]] – hPRS + CFTR peptide <br />
 
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**[[6fel]] – hPRS + CAMKK 2 peptide <br />
 
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*14-3-3 protein β/α
 
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**[[2bq0]], [[4dnk]] – hPRS <br />
 
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**[[2c23]] – hPRS + exoenzyme S peptide <br />
 
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**[[5n10]] – hPRS + estrogen receptor peptide <br />
 
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**[[4gnt]] – mPRS + CHREBP peptide - mouse<br />
 
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**[[5f74]] – mPRS + CHREBP + AMP<br />
 
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*14-3-3 protein θ
 
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**[[5iqp]] – hPRS <br />
 
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**[[2btp]] – hPRS + phosphopeptide <br />
 
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*14-3-3 protein η
 
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**[[2c63]], [[2c74]] – hPRS + phosphopeptide <br />
 
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**[[5yqg]] – hPRS + NUMB peptide <br />
 
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*14-3-3 protein ε
 
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**[[2br9]], [[6eih]] – hPRS + phosphopeptide <br />
 
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**[[3ual]], [[3ubw]] – hPRS + myeloid leukemia factor 1 peptide <br />
 
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*14-3-3 protein
 
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**[[3efz]] – PRS + phosphoserine – ''Cryptosporidium parvum''<br />
 
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**[[4f7r]] – PRS – ''Giardia intestinalis''<br />
 
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*14-3-3-like protein C
 
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**[[1o9c]], [[1o9e]] – tPRS - tobacco<br />
 
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**[[1o9d]], [[1o9f]], [[2o98]], [[3e6y]] – tPRS + H+ ATPase peptide<br />
 
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**[[5nwi]], [[5nwj]], [[5nwk]] – tPRS + potassium channel peptide <br />
 
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**[[3m50]], [[3m51]] – tPRS + PMA2 peptide + stabilizer<br />
 
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*14-3-3-like protein GF14-C
 
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**[[3axy]] – PRS + HD3A + OSFD1 - rice<br />
 
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*14-3-3-like protein E
 
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**[[4dx0]] – tPRS + PMA2 peptide + stabilizer<br />
 
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}}
 
== References ==
== References ==

Revision as of 08:58, 20 February 2019

Structure of human 14-3-3 protein ζ with phosphopeptide (yellow) (PDB code 1qja).

Drag the structure with the mouse to rotate


References

  1. Benzinger A, Popowicz GM, Joy JK, Majumdar S, Holak TA, Hermeking H. The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Res. 2005 Apr;15(4):219-27. PMID:15857576 doi:10.1038/sj.cr.7290290

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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