3-phosphoinositide-dependent protein kinase 1

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[[Pdk1 3D structures]]
[[Pdk1 3D structures]]
</StructureSection>
</StructureSection>
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== 3D Structures of Pdk1==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Pdk1 kinase domain
 
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**[[1h1w]] – hPdk1 + PSer – human <br />
 
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**[[1uu3]], [[1uu7]], [[1uu8]], [[1uu9]], [[1uvr]], [[1z5m]], [[2pe0]], [[2pe1]], [[2pe2]], [[3h9o]], [[2xch]], [[2xck]], [[3qcq]], [[3qcs]], [[3qcx]], [[3qcy]], [[3qd0]], [[3qd3]], [[3qd4]], [[3nus]], [[3nuu]], [[3nuy]], [[3nun]], [[3sc1]], [[3rwp]], [[3rwq]], [[5hkm]], [[5hng]], [[5ho7]], [[5ho8]] – hPdk1 + PSer + inhibitor <br />
 
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**[[3orx]], [[3orz]], [[3otu]], [[3qc4]], [[3rcj]], [[5lvl]], [[4xx9]], [[5ack]] – hPdk1 (mutant) + PSer + inhibitor <br />
 
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**[[2r7b]], [[3ion]], [[3iop]], [[3nax]], [[3nay]] – hPdk1 + inhibitor <br />
 
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**[[3pwy]] – hPdk1 (mutant) + inhibitor <br />
 
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**[[1oky]], [[1okz]] – hPdk1 + PSer + staurosporine <br />
 
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**[[2biy]], [[3hrc]] – hPdk1 (mutant) + ATP <br />
 
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**[[4ct1]] – hPdk1 (mutant) + ATP + PSer + PS315<br />
 
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**[[5lvo]] – hPdk1 (mutant) + ATP + PSer + PSE10<br />
 
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**[[5lvp]] – hPdk1 (mutant) + ATP + PSer + peptide<br />
 
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**[[4ct2]] – hPdk1 (mutant) + ATP + PSer <br />
 
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**[[5lvm]] – hPdk1 (mutant) + adenine + PSer <br />
 
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**[[5lvn]] – hPdk1 (mutant) + adenosine + PSer <br />
 
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**[[4rqk]], [[4rqv]], [[5mrd]] – hPdk1 (mutant) + ATP + PSer + inhibitor<br />
 
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**[[4rrv]] – hPdk1 (mutant) + ATP + PSer + serine/threonine protein kinase N2<br />
 
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**[[3hrf]], [[4a06]], [[4a07]], [[4aw0]], [[4aw1]] – hPdk1 (mutant) + PSer + ATP + activator<br />
 
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*Pdk1 PH domain
 
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**[[1w1h]] – hPdkl <br />
 
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**[[2vki]] – hPdk1 (mutant)<br />
 
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**[[1w1d]], [[1w1g]] – hPdk1 + inositol phosphate <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:24, 20 February 2019

Human Pdk1 kinase domain containing phosphorylated serine 241 complex with pyrazoloquinazoline inhibitor, sulfate and glycerol (PDB entry 2xch)

Drag the structure with the mouse to rotate

References

  1. ↑ Mora A, Komander D, van Aalten DM, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol. 2004 Apr;15(2):161-70. PMID:15209375

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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