5zk5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Stapled-peptides tailored against initiation of translation== | |
| - | + | <StructureSection load='5zk5' size='340' side='right' caption='[[5zk5]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5zk5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZK5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zk5 OCA], [http://pdbe.org/5zk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5zk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zk5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Auvin, S]] | ||
| + | [[Category: Bashir, T]] | ||
| + | [[Category: Brown, C J]] | ||
[[Category: Ciesielski, F]] | [[Category: Ciesielski, F]] | ||
| - | [[Category: Brown, C.J]] | ||
| - | [[Category: Tsomia, N]] | ||
| - | [[Category: Nakhle, J]] | ||
[[Category: Frosi, Y]] | [[Category: Frosi, Y]] | ||
| - | [[Category: Verma, C.S]] | ||
[[Category: Lama, D]] | [[Category: Lama, D]] | ||
| + | [[Category: Lane, D P]] | ||
[[Category: Liberator, A]] | [[Category: Liberator, A]] | ||
| - | [[Category: | + | [[Category: Nakhle, J]] |
| + | [[Category: Tsomia, N]] | ||
[[Category: Uhring, M]] | [[Category: Uhring, M]] | ||
| - | [[Category: | + | [[Category: Verma, C S]] |
| - | [[Category: | + | [[Category: Cap dependent translation]] |
| + | [[Category: Rna binding protein]] | ||
Revision as of 06:35, 21 February 2019
Stapled-peptides tailored against initiation of translation
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