6npn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine-3-hydroxyindazole inhibitor== | |
| - | + | <StructureSection load='6npn' size='340' side='right' caption='[[6npn]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6npn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NPN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KWJ:(7R)-7-methyl-2-[(3-oxo-2,3-dihydro-1H-indazol-6-yl)amino]-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one'>KWJ</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | [[Category: Elkins, J | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6npn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6npn OCA], [http://pdbe.org/6npn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6npn RCSB], [http://www.ebi.ac.uk/pdbsum/6npn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6npn ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Arruda, P]] | ||
| + | [[Category: Azevedo, A]] | ||
| + | [[Category: Counago, R M]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Elkins, J M]] | ||
[[Category: Ferreira, M]] | [[Category: Ferreira, M]] | ||
[[Category: Gama, F]] | [[Category: Gama, F]] | ||
| - | [[Category: Massirer, K.B]] | ||
[[Category: Guimaraes, C]] | [[Category: Guimaraes, C]] | ||
| - | [[Category: Takarada, J.E]] | ||
| - | [[Category: Azevedo, A]] | ||
| - | [[Category: Counago, R.M]] | ||
| - | [[Category: Dos Reis, C.V]] | ||
| - | [[Category: Edwards, A.M]] | ||
| - | [[Category: Arruda, P]] | ||
| - | [[Category: Structural Genomics Consortium (Sgc)]] | ||
[[Category: Mascarello, A]] | [[Category: Mascarello, A]] | ||
| + | [[Category: Massirer, K B]] | ||
| + | [[Category: Reis, C V.dos]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Takarada, J E]] | ||
| + | [[Category: Protein kinase domain]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 06:56, 21 February 2019
Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine-3-hydroxyindazole inhibitor
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Categories: Non-specific serine/threonine protein kinase | Arruda, P | Azevedo, A | Counago, R M | Edwards, A M | Elkins, J M | Ferreira, M | Gama, F | Guimaraes, C | Mascarello, A | Massirer, K B | Reis, C V.dos | Structural genomic | Takarada, J E | Protein kinase domain | Sgc | Transferase | Transferase-transferase inhibitor complex
