5'-deoxy-5'-methylthioadenosine phosphorylase
From Proteopedia
(Difference between revisions)
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MTAP is a potential target of chemotherapy. More than 20% of human various cancer cells do not show MTAP activity. | MTAP is a potential target of chemotherapy. More than 20% of human various cancer cells do not show MTAP activity. | ||
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| + | ==3D structures of 5’-deoxy-5’-methylthioadenosine phosphorylase== | ||
| + | [[5’-deoxy-5’-methylthioadenosine phosphorylase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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**[[1cg6]] – hMTAP (mutant) + MTA<br /> | **[[1cg6]] – hMTAP (mutant) + MTA<br /> | ||
| + | **[[5eub]] - hMTAP + MTA derivative<br /> | ||
**[[2a8y]], [[3t94]] – SsMTAP + MTA <br /> | **[[2a8y]], [[3t94]] – SsMTAP + MTA <br /> | ||
*MTAP complex with antibiotics | *MTAP complex with antibiotics | ||
| - | **[[1sd1]], [[1sd2]] – hMTAP + antibiotic<br /> | + | **[[1sd1]], [[1sd2]], [[5tc5]], [[5tc6]], [[5tc7]], [[5tc8]] – hMTAP + antibiotic<br /> |
**[[4l5a]] – SmMTAP + antibiotic <br /> | **[[4l5a]] – SmMTAP + antibiotic <br /> | ||
Revision as of 08:19, 21 February 2019
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3D structures of 5’-deoxy-5’-methylthioadenosine phosphorylase
Updated on 21-February-2019
References
- ↑ Appleby TC, Erion MD, Ealick SE. The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis. Structure. 1999 Jun 15;7(6):629-41. PMID:10404592
