Dedicator of cytokinesis protein

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Revision as of 10:51, 21 February 2019

Human dedicator of cytokinesis protein 9 dimer DHR-2 domain (grey and aqua) complex with Cdc42 (green and olive) and GDP (PDB code 2wmn)

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Updated on 21-February-2019

↑ Su HC. Dedicator of cytokinesis 8 (DOCK8) deficiency. Curr Opin Allergy Clin Immunol. 2010 Dec;10(6):515-20. doi:, 10.1097/ACI.0b013e32833fd718. PMID:20864884 doi:http://dx.doi.org/10.1097/ACI.0b013e32833fd718
↑ Yang J, Zhang Z, Roe SM, Marshall CJ, Barford D. Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Science. 2009 Sep 11;325(5946):1398-402. PMID:19745154 doi:325/5946/1398

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 == Structural highlights ==
-<scene name='75/752233/Cv/5'>Human dedicator of cytokinesis protein 9 DHR-2 domain (DOCK9) complex with Cdc42 and GDP</scene> (PDB code [[2wmn]]). <scene name='75/752233/Cv/4'>GDP interacts with Cdc42</scene>. Water molecules shown as red spheres. <scene name='75/752233/Cv/7'>DOCK9 has extensive contacts with Cdc42</scene><ref>PMID:19745154</ref>.
+<scene name='75/752233/Cv/8'>Human dedicator of cytokinesis protein 9 DHR-2 domain (DOCK9) complex with Cdc42 and GDP</scene> (PDB code [[2wmn]]). <scene name='75/752233/Cv/9'>GDP interacts with Cdc42</scene>. Water molecules shown as red spheres. <scene name='75/752233/Cv/10'>DOCK9 has extensive contacts with Cdc42</scene><ref>PMID:19745154</ref>.
 </StructureSection>