Dihydroorotate dehydrogenase
From Proteopedia
(Difference between revisions)
| Line 10: | Line 10: | ||
== Structural highlights == | == Structural highlights == | ||
| - | <scene name='54/540163/Cv/ | + | <scene name='54/540163/Cv/8'>DHOD FMN/orotate binding site</scene>. The <scene name='54/540163/Cv/9'>inhibitor brequinar binds DHOD in the quinone binding channel</scene>. See also this <scene name='54/540163/Cv/10'>representation of brequinar binding</scene>. <ref>PMID:16406782</ref> |
</StructureSection> | </StructureSection> | ||
== 3D Structures of dihydroorotate dehydrogenase == | == 3D Structures of dihydroorotate dehydrogenase == | ||
Revision as of 10:37, 24 February 2019
| |||||||||||
3D Structures of dihydroorotate dehydrogenase
Updated on 24-February-2019
References
- ↑ Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL. On dihydroorotate dehydrogenases and their inhibitors and uses. J Med Chem. 2013 Apr 25;56(8):3148-67. doi: 10.1021/jm301848w. Epub 2013 Mar 20. PMID:23452331 doi:http://dx.doi.org/10.1021/jm301848w
- ↑ Hurt DE, Sutton AE, Clardy J. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1610-5. Epub 2006 Jan 10. PMID:16406782 doi:S0960-894X(05)01599-4
